At RestorEar, we are committed to pushing the boundaries of auditory technology to provide individuals with exceptional hearing solutions. Extensive research has unveiled the transformative potential of mild therapeutic hypothermia in preserving residual hearing, reducing inflammation, and protecting against auditory trauma– the very science that inspired the creation of ReBound. Below are just a few examples of studies highlighting the use of cooling for auditory rehabilitation. 

A cool approach to reducing electrode-induced trauma: localized therapeutic hypothermia conserves residual hearing in cochlear implantation. [Tamames et al., 2016] In this pioneering study, researchers investigated the use of localized therapeutic hypothermia to minimize trauma caused by cochlear implant electrode insertion. By cooling the cochlea during the procedure, they discovered that residual hearing was better preserved. These findings provide a promising opportunity for individuals considering cochlear implants to retain their natural hearing abilities alongside the benefits of the implant and offer insight into the mechanisms involved in cooling for auditory benefits.

Additive protective effects of delayed mild therapeutic hypothermia and antioxidants on PC12 cells exposed to oxidative stress. [Singh et al., 2020] This study explored the combined effects of mild therapeutic hypothermia and antioxidants in protecting cells from oxidative stress, a major factor in hearing loss. The researchers demonstrated the additive protective effects of these interventions, effectively reducing cellular damage caused by oxidative stress. These findings hold great potential for enhancing the biocompatibility of cochlear implants, safeguarding cells from stress-related damage, and improving the longevity of the implant.

Mild therapeutic hypothermia protects against inflammatory and proapoptotic processes in the rat model of cochlear implant trauma. [Sangaletti et al., 2023] Building upon previous research, this recent study examined the protective effects of mild therapeutic hypothermia in a rat model of cochlear implant trauma. The findings revealed that mild therapeutic hypothermia effectively reduced both inflammatory and proapoptotic processes, providing a shield for cochlear tissue. These exciting results further underscore the potential of incorporating mild therapeutic hypothermia as a standard practice during cochlear implant surgeries to enhance patient outcomes.

Protective role of hypothermia in cochlear implantation: A review. [Lorens et al., 2021] This comprehensive review article explores the protective role of hypothermia in cochlear implantation. The authors discuss the mechanisms underlying the beneficial effects of hypothermia, such as reduced inflammation and preservation of cochlear structures. The review provides valuable insights into the potential applications of hypothermia in improving cochlear implant outcomes.

Hypothermia protects the cochlea from noise damage. [Henry et al., 1984] In this study, researchers investigated the protective effects of hypothermia on the cochlea against noise damage. They observed that hypothermia significantly reduced cochlear damage caused by noise exposure, preserving hearing function. These findings highlight the potential of mild therapeutic hypothermia not only in the context of cochlear implantation but also as a protective measure against other forms of auditory trauma.

Hyperthermia exacerbates and hypothermia protects from noise-induced threshold elevation of the cochlear nerve envelope response in the C57BL/6J mouse. [Henry et al., 2003] This study examined the effects of hyperthermia and hypothermia on noise-induced threshold elevation of the cochlear nerve response in mice. The researchers found that hyperthermia exacerbated the threshold elevation, while hypothermia provided protection, mitigating the detrimental effects of noise exposure. These findings further support the potential of mild therapeutic hypothermia as a preventive strategy against noise-induced hearing loss.

Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea. [Spankovich and Walters, 2022] This study delves into the mechanisms underlying the protective effects of mild therapeutic hypothermia on hair cell survival in the cochlea. The researchers explored the potential mechanisms through which hypothermia preserves hair cell function and viability. Understanding these mechanisms is vital for developing targeted therapies to mitigate hair cell damage and promote auditory recovery.

Mild therapeutic hypothermia has emerged as a powerful intervention in auditory rehabilitation, holding immense potential as a post-trauma therapy. The studies discussed highlight the significant advancements made in understanding the benefits of mild therapeutic hypothermia for hearing health. At RestorEar, we are at the forefront of harnessing this transformative technology to provide individuals with unparalleled hearing experiences. We designed ReBound after years of research, synthesizing scientific breakthroughs like the studies highlighted above. With ReBound, we can unlock the full potential of mild therapeutic hypothermia and shape the future of auditory rehabilitation.